HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoate → (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoate | HCID 46180106 | — |
| Reactant | (E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid | HCID 46180242 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid | HCID 46180319 | — |
Reaction Steps
Compound 42a was prepared from 41a (0.959 g, 2.90 mmol) as described above for 29a to give 0.872 g (2.84 mmol, 98%) of the product as a tan solid following flash chromatography (3:17 acetone:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09089605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-103d989bfa564e4eb0fa86c3c1459511 |
| Source note | uspto-grants-2015_07 |