HCID 46180045, compound → (E)-3-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylpropenoic acid

HRID 1527687Notes

Reaction equation

HRID 1527687 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([CH3:15])[C:4]=1/[CH:16]=[C:17](\[CH3:23])/[C:18]([O:20]CC)=[O:19].COC1C2C(=CC=CC=2)C(OC)=CC=1/C=C(\C)/C(O)=O>CC(C)=O>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([CH3:15])[C:4]=1/[CH:16]=[C:17](\[CH3:23])/[C:18]([OH:20])=[O:19]

Participants

4

Reactant 2

HCID 46180045HCID 46180045, compoundHCID 46180242(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

Product 1

HCID 46180244(E)-3-(1,4-dimethoxy-3-methylnaphthalen-2-yl)-2-methylpropenoic acid

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Compound 99a was prepared from 98a (0.176 g, 0.560 mmol) as described above for 29a to give 0.134 g (0.468 mmol, 83%) of the product as a light yellow solid following flash chromatography (3:17 acetone:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

Workup

  1. customto give

Sources & evidence

ORD record
ord-21f7f9f859b048b3ac10b6cf1eb65333
Source dataset
uspto-grants-2015_07
Patent number
US09089605B2

Reaction notes

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