Ethyl (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoate → (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

HRID 1527690Notes

Reaction equation

HRID 1527690 reaction equation
[Br:1][C:2]1[C:3](/[CH:16]=[C:17](\[CH3:23])/[C:18]([O:20]CC)=[O:19])=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2.COC1C2C(=CC=CC=2)C(OC)=CC=1/C=C(\C)/C(O)=O>>[Br:1][C:2]1[C:3](/[CH:16]=[C:17](\[CH3:23])/[C:18]([OH:20])=[O:19])=[C:4]([O:14][CH3:15])[C:5]2[C:10]([C:11]=1[O:12][CH3:13])=[CH:9][CH:8]=[CH:7][CH:6]=2

Participants

3

Reactant 2

HCID 46180107Ethyl (E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoateHCID 46180242(E)-3-(1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

Product 1

HCID 46180385(E)-3-(3-bromo-1,4-dimethoxynaphthalen-2-yl)-2-methylpropenoic acid

Procedure

Compound 99e was prepared from 98e (0.314 g, 0.828 mmol) as described above for 29a to give 0.291 g (0.829 mmol, 100%) of the product as a white solid following recrystallization from Et2O/hexanes.

Workup

  1. customto give

Sources & evidence

ORD record
ord-a81f653b52494f49890e3f8d4247caff
Source dataset
uspto-grants-2015_07
Patent number
US09089605B2

Reaction notes

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