HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid → (E)-3-(3-chloro-1,4-naphthoquinon-2-yl)-2-propylpropenoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid | HCID 25235467 | — |
| Reactant | (E)-3-(3-chloro-1,4-dimethoxynaphthalen-2-yl)-2-propylpropenoic acid | HCID 68772573 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (E)-3-(3-chloro-1,4-naphthoquinon-2-yl)-2-propylpropenoic acid | HCID 68775213 | — |
Reaction Steps
Compound 43b was prepared from 42b (0.053 g, 0.16 mmol) as described above for 39a to give 0.016 g (0.05 mmol, 33%) of the product as a yellow solid following flash chromatography (2:3 acetone:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09089605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-2159dd73c7c944acbf4f3ecbaca2c43c |
| Source note | uspto-grants-2015_07 |