HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Bromo-1,4-dioxonaphthalen-2-yl)propanoic acid → (2R/S)-3-(3-bromo-1,4-naphthoquinon-2-yl)-2-methylpropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Bromo-1,4-dioxonaphthalen-2-yl)propanoic acid | HCID 45487236 | — |
| Reactant | Ethyl (2R/S)-3-(3-bromo-1,4-naphthoquinon-2-yl)-2-methylpropionate | HCID 70835151 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (2R/S)-3-(3-bromo-1,4-naphthoquinon-2-yl)-2-methylpropionic acid | HCID 59583711 | — |
Reaction Steps
Compound 69b was prepared from racemic 68b (0.027 g, 0.08 mmol) as described above for 69a to give 0.016 g (0.05 mmol, 63%) of the product as a yellow solid following flash chromatography (1:4 acetone:hexanes 0 to 0.5% AcOH) and recrystallization from Et2O/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09089605B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-665a1d651c3a4d16868285ecab5507f0 |
| Source note | uspto-grants-2015_07 |