3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide → HCID 178425836, compound

HRID 1527857Notes

Reaction equation

HRID 1527857 reaction equation
[C:1]([C:3]1[C:4]2[NH:11][CH:10]=[N:9][C:5]=2[CH:6]=[N:7][CH:8]=1)#[CH:2].I[C:13]1[CH:14]=[C:15]([CH:37]=[CH:38][C:39]=1[CH3:40])[C:16]([NH:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][N:26]2[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]2)=[C:21]([C:33]([F:36])([F:35])[F:34])[CH:20]=1)=[O:17]>>[NH:11]1[C:4]2[C:3]([C:1]#[C:2][C:38]3[CH:37]=[C:15]([CH:14]=[CH:13][C:39]=3[CH3:40])[C:16]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:25][N:26]4[CH2:31][CH2:30][N:29]([CH3:32])[CH2:28][CH2:27]4)=[C:21]([C:33]([F:36])([F:35])[F:34])[CH:20]=3)=[O:17])=[CH:8][N:7]=[CH:6][C:5]=2[N:9]=[CH:10]1

Participants

3

Reactant 2

HCID 468389103-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamideHCID 178437114HCID 178437114, compound

Product 1

HCID 178425836HCID 178425836, compound

Procedure

The title compound can be synthesized from 7-ethynyl-1H-imidazo[4,5-c]pyridine and 3-iodo-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for Example 1. 7-ethynyl-1H-imidazo[4,5-c]pyridine is prepared from 7-bromo-1H-imidazo[4,5-c]pyridine and ethynyltrimethylsilane according to the 2 steps procedure described in Example 1.

Sources & evidence

ORD record
ord-463af891f1e2416a8f27b5ae89e6c16e
Source dataset
uspto-grants-2015_07
Patent number
US09090561B2

Reaction notes

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