3-Ethynylpyridine → HCID 68916022, compound

HRID 1527864Notes

Reaction equation

HRID 1527864 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1)#[CH:2].I[C:10]1[CH:11]=[C:12]([CH:32]=[CH:33][C:34]=1[CH3:35])[C:13]([NH:15][C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([N:26]2[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]2)[CH:17]=1)=[O:14]>>[CH3:35][C:34]1[CH:10]=[CH:11][C:12]([C:13]([NH:15][C:16]2[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[C:18]([N:26]3[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]3)[CH:17]=2)=[O:14])=[CH:32][C:33]=1[C:2]#[C:1][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1860033-EthynylpyridineHCID 177521583-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide

Product 1

HCID 68916022HCID 68916022, compound

Procedure

The title compound can be synthesized from 3-ethynylpyridine and 3-Iodo-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide in a manner similar to that described for Example 1. 3-ethynylpridine was prepared from 3-bromopyridine and ethynyltrimethylsilane according to the 2 steps procedure described in Example 1.

Sources & evidence

ORD record
ord-80c528ba65744441af1527ee93053d82
Source dataset
uspto-grants-2015_07
Patent number
US09090561B2

Reaction notes

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