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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1527889Generated: November 3, 2026

4-(4-Methylpiperazin-1-ylmethyl)-3-trimethylsilylaniline → 3-{[6-(acetylamino)pyridin-3-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trimethylsilyl)phenyl}benzamide

https://huagongshe.com/reaction/1527889

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(4-Methylpiperazin-1-ylmethyl)-3-trimethylsilylanilineHCID 57775110—
ReactantHCID 68899408HCID 68899408—
Product3-{[6-(acetylamino)pyridin-3-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trimethylsilyl)phenyl}benzamideHCID 57775221—

Reaction Steps

This compound can be made in a similar way described in alternative synthesis of example 1 using 3-{[6-(acetylamino)pyridin-3-yl]ethynyl}-4-methylbenzoic acid and 4-[(4-methylpiperazin-1-yl)methyl]-3-(trimethylsilyl)aniline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090561B2
Source datasetuspto-grants-2015_07
ORD IDord-f9c24411fa044a73ab0e255b893f1efe
Source noteuspto-grants-2015_07