反应详情

To a solution of 3-iodo-4-methylbenzoic acid (1.5 g, 5.7 mmol) in 25 ml of ethanol was dropped in 0.5 ml of concentrated sulfuric acid. The reaction was refluxed overnight. TLC (Ethyl Acetate/Hexane 1:10) indicated the completion of the esterification. The extra ethanol was evaporated and the residue was dissolved in 30 ml of dichloromethane, which was washed with water (10 ml) and brine (10 ml), dried, and evaporated to a thick oil. A white solid was obtained after drying under vacuo (1.56 g, in 95% yield).

1. temperatureThe reaction was refluxed overnight
2. customThe extra ethanol was evaporated
3. dissolutionthe residue was dissolved in 30 ml of dichloromethane
4. washwhich was washed with water (10 ml) and brine (10 ml)
5. customdried
6. customevaporated to a thick oil
7. customA white solid was obtained
8. customafter drying under vacuo (1.56 g, in 95% yield)