Sodium Hydroxide → HCID 71611732, compound

Participants

Reaction Steps

To a solution of ester 3 (0.086 g, 0.25 mmol) in MeOH (10 mL) was added a solution of 2 M NaOH 2 mL (0.40 mmol) and the resulting mixture was stirred at RT for 4 hours. The volatiles were removed in vacuo. The residue was diluted with water (5 mL) and acidified to pH 1 with 2 M HCl. The acid 4 was isolated by filtration as a white solid and washed with water and dried overnight over KOH in a dessicator to yield 1-(5-chloro-2-cyclopentylmethoxy-benzyl)-5-methyl-1H-pyrazole-3-carboxylic acid, 4, as a white solid.

Provenance & Evidence