Hydrochloric Acid → HCID 86684814, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 4-(4-(3-(3-methoxypyridazin-4-yl)-3-oxo-1-o-tolylpropyl)-phenyl)piperidine-1-carboxylate (118 mg, 195 μmol) in 1,4-dioxane (4 mL) was added 37% aq. hydrochloric acid solution (0.32 mL, 3.9 mmol), then after 30 min the reaction mixture was partitioned between ethyl acetate and sat, aq. sodium hydrogencarbonte-solution. The organic layer was washed with brine, dried over magnesium sulfate, filtered, and evaporated. Chromatography (SiO2; gradient dichloromethane to dichloromethane/methanol/25% aq. ammonia solution 90:10:0.25) afforded the title compound (64 mg, 79%). Orange gum, MS: 416.2 [M+H]+.

Provenance & Evidence