Water → HCID 86684818, compound

Participants

Reaction Steps

Water (0.2 mL) was added to a suspension of molybdenum(V) chloride (160 mg, 0.56 mmol) in THF (1 mL), then after 5 min zinc dust (60 mg, 0.92 mmol) was added portionwise, followed by (S)-6-(3-(4-bromophenyl)-3-o-tolylpropanoyl)-3-methoxypyridazine 1-oxide (100 mg, 0.23 mmol). The mixture was heated at reflux for 90 min, then partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over magnesium sulfate, filtered, and evaporated in vacuo. Chromatography (SiO2; heptane-ethyl acetate gradient) afforded the title compound (36 mg, 38%). Colorless gum, MS: 411.2 [M+H]+.

Provenance & Evidence