反应详情

4-(2-t-Butoxycarbonylaminoethyl)phenoxymethylphosphonic acid, diethyl ester (2.856 g, 9.95 mMol) in methylene chloride (300 ml) and trifluoracetic acid (16 ml) was stirred at room temperature for 5 h. The solution was concentrated under reduced pressure and product dried under in vacuo. The trifluoacetic acid salt was neutralized with aqueous sodium carbonate and extracted with dichloromethane containing a small proportion of methanol (5×100 ml). The combined organic layers were dried over sodium sulfate and evaporated to dryness to give the title compound as a pale yellow gum.

1. concentrationThe solution was concentrated under reduced pressure and product
2. customdried under in vacuo
3. extractionextracted with dichloromethane containing a small proportion of methanol (5×100 ml)
4. dry with materialThe combined organic layers were dried over sodium sulfate
5. customevaporated to dryness