HuagongsheHuagongshe Chemistry Print Report · For research reference only
Menadione → 4-(3-Methyl-1,4-dioxo-1,4,4a,8a-tetrahydro-naphthalen-2-ylmethyl)-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Menadione | HCID 4055 | — |
| Reactant | 4-(Carboxymethyl)benzoic Acid | HCID 220005 | — |
| Product | 4-(3-Methyl-1,4-dioxo-1,4,4a,8a-tetrahydro-naphthalen-2-ylmethyl)-benzoic acid | HCID 67057854 | 12% |
Reaction Steps
As starting materials for the coupling reaction menadione and 4-carboxyphenylacetic acid were used. Synthesis is realized according to the general procedure described in general procedure of example 1. After chromatography on silica gel (petroleum ether:CH2Cl2=1:3, UV), 102 mg (0.33 mmol, 12% yield) of P_TM50 were isolated as yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090549B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-6ad5c6464b7145359406d538e7986104 |
| Source note | uspto-grants-2015_07 |