Formamide → 7-Bromo-3,4-dihydroquinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

2-Amino-4-bromobenzoic acid (15.5 g) was dissolved in 100 mL of formamide and the solution was heated at 190° C. for 10 h. After the reaction was cooled to room temperature, the solid was collected via filtration, rinsed with water, and dried to give 10.5 g of 7-bromo-4-quinazolinone, LCMS ESI(+) m/z: 225/227 (M+1).

Provenance & Evidence