HCID 12625721, compound → HCID 68310699, compound

HRID 1528032Notes

Reaction equation

HRID 1528032 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([C:21]#[C:22]C4CCOC4)=[C:17]([NH2:20])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].C([C@@H:30]1[CH2:34][CH2:33][CH2:32][O:31]1)#C>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([C:21]#[C:22][C@@H:30]4[CH2:34][CH2:33][CH2:32][O:31]4)=[C:17]([NH2:20])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

Participants

3

Reactant 2

HCID 12625721HCID 12625721, compound3×HCID 68288525HCID 68288525, compound

Product 1

HCID 68310699HCID 68310699, compound

Procedure

Compound 2.3 was prepared with the same procedure as the preparation of Compound 1.2, using (S)-2-ethynyl-tetrahydrofuran (Compound 2.2) instead of (S)-2-ethynyl-tetrahydrofuran (Compound 1.1). MS (ESI) m/z=383 (M+1).

Sources & evidence

ORD record
ord-f54cae2ccd0a40459c712cd888a77e4c
Source dataset
uspto-grants-2015_07
Patent number
US09090588B2

Reaction notes

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