HCID 89896086, compound → HCID 89882652, compound

Participants

Reaction Steps

3-benyloxy-2-(3,4-difluorophenyl)-5,7-dihydroxy-6,8-di(3-methyl-2-buten-1-yl)-4H-benzopyran-4-one (30 mg) was dissolved in 10 mL methanol, and 5% Pd/C (10 mg) was added. The reaction mixture was hydrogenated at 0° C. under atmospheric pressure for 5 hr. The mixture was filtered and the filtrate was concentrated. The residue was purified by silica gel column chromatography (eluent:methol/dichloromethane, 1:50) to give the desired compound (6 mg, yield 24%). 1H NMR (400 MHz, CDCl3): δ=11.94 (s, 1H), 8.08-7.98 (m, 2H), 7.31 (dd, 1H, J1=18.4 Hz, J2=8.8 Hz), 6.76 (s, 1H), 6.45 (s, 1H), 5.28-5.22 (m, 2H), 3.56 (d, 2H, J=6.8 Hz), 3.47 (d, 2H, J=7.2 Hz), 1.86 (s, 3H), 1.85 (s, 3H), 1.77 (s, 3H), 1.76 (s, 3H); LC-MS (ESI) m/z 442.9 [M+H]+.

Provenance & Evidence