HCID 71272547, compound → HCID 68014668, compound

Participants

Reaction Steps

A suspension of 1-[2-(benzyloxy)-4-(3,4-difluoro-1H-pyrrol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (3.20 g) and 10% palladium on carbon (containing water (50%), 3.20 g) in acetic acid (100 mL) was stirred at room temperature for 3 hr under a hydrogen atmosphere. The palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by SFC (column: CHIRALPAK ADH (trade name), 20 mmID×250 mL, manufactured by DAICEL CHEMICAL INDUSTRIES, LTD., mobile phase: carbon dioxide/2-propanol/acetonitrile=700/150/150 (v/v/v)), and the obtained fraction was concentrated under reduced pressure. The residue was recrystallized from acetone to give the title compound (1.24 g).

Provenance & Evidence