HCID 86686556, compound → HCID 86686557, compound

HRID 1528068Notes

Reaction equation

HRID 1528068 reaction equation
[F:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH3:16])([CH3:15])[C:5](=[O:14])[NH:6]2>[Pd].CO>[NH2:11][C:10]1[C:2]([F:1])=[C:3]2[C:7](=[CH:8][CH:9]=1)[NH:6][C:5](=[O:14])[C:4]2([CH3:15])[CH3:16]

Participants

4

Reactant 1

HCID 86686556HCID 86686556, compound

Product 1

HCID 86686557HCID 86686557, compoundYield 95.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 4-fluoro-3,3-dimethyl-5-nitro-1,3-dihydro-2H-indol-2-one (3.5 g), palladium on carbon (containing water (50%), 2.0 g) in methanol (150 mL) was stirred at room temperature for 3 hr under a hydrogen atmosphere. The palladium on carbon was removed by filtration, and the filtrate was concentrated under reduced pressure to give the title compound (2.9 g).

Workup

  1. customThe palladium on carbon was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d1901db62d9f45908933aa299b6b072e
Source dataset
uspto-grants-2015_07
Patent number
US09090586B2

Reaction notes

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