Benzhydrylamine → HCID 86686566, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,3-difluoro-N-methyl-6-nitroaniline (2.66 g), 1,1-diphenylmethanamine (5.18 g), diisopropylethylamine (4.56 g) and butan-1-ol (26.6 mL) was heated at 200° C. for 2 hr using a microwave reactor. To the reaction mixture was added saturated sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.47 g).

Provenance & Evidence