Methyl iodide → HCID 86686572, compound

Participants

Reaction Steps

To a solution of 4′-fluoro-5′-nitrospiro[cyclobutane-1,3′-indol]-2′ (1′H)-one (300 mg) and sodium hydride (36.6 mg) in DMF (10 mL) was added methyl iodide (0.395 mL) at 0° C., and the mixture was stirred at room temperature for 1 hr under a nitrogen atmosphere. To the reaction mixture was added saturated aqueous ammonium chloride solution at 0° C., and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (282 mg).

Provenance & Evidence