2-Fluoroethyl bromide → HCID 57520674, compound

HRID 1528108Notes

Reaction equation

HRID 1528108 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[C:7]2[NH:12][C:13]([NH:15][C:16]1[N:21]=[C:20]([CH:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:19]=[CH:18][CH:17]=1)=[O:14].BrCCF.[F:32][CH:33]([F:36])[CH2:34]I>>[F:32][CH:33]([F:36])[CH2:34][N:25]1[CH2:24][CH2:23][CH:22]([C:20]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:15][C:13]([NH:12][C:7]3[C:6]4[C:11](=[C:2]([F:1])[CH:3]=[CH:4][CH:5]=4)[N:10]=[CH:9][CH:8]=3)=[O:14])[N:21]=2)[CH2:27][CH2:26]1

Participants

4

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 38335651,1-Difluoro-2-iodoethaneHCID 57520575HCID 57520575, compound

Product 1

HCID 57520674HCID 57520674, compound

Procedure

The title compound was prepared as described in example 32, substituting 1-(6-(piperidin-4-yl)quinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)urea by 1-(8-fluoro-quinolin-4-yl)-3-(1′,2′,3′,4′,5′,6′-hexahydro-[2,4′]bipyridinyl-6-yl)-urea (example 62) and 1-bromo-2-fluoroethane by 1,1-difluoro-2-iodoethane.

Sources & evidence

ORD record
ord-d830db1facfe4c48849cbff80f75fff3
Source dataset
uspto-grants-2015_07
Patent number
US09090592B2

Reaction notes

Loading…