1,4-Butanediol, mono-trimethylsilyl ether → HCID 71261586, compound

HRID 1528143Notes

Reaction equation

HRID 1528143 reaction equation
[NH2:1][C:2]1[S:6][C:5]([C:7]2[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=2[F:14])=[N:4][C:3]=1[C:15]([NH:17][C:18]1[C:19]([O:24][CH:25]2[CH2:30]CNCC2)=[N:20][CH:21]=[N:22][CH:23]=1)=[O:16].C[Si](C)(C)[O:33][CH2:34][CH2:35]CCO>>[NH2:1][C:2]1[S:6][C:5]([C:7]2[C:8]([F:14])=[CH:9][CH:10]=[CH:11][C:12]=2[F:13])=[N:4][C:3]=1[C:15]([NH:17][C:18]1[C:19]([O:24][CH2:25][CH2:30][CH2:35][CH2:34][OH:33])=[N:20][CH:21]=[N:22][CH:23]=1)=[O:16]

Participants

3

Reactant 2

HCID 5240071,4-Butanediol, mono-trimethylsilyl etherHCID 71261423HCID 71261423, compound

Product 1

HCID 71261586HCID 71261586, compound

Procedure

Following the procedure described in Example 1, and substituting Compound 4 in Step (1) with 4-((trimethylsilyl)oxy)butan-1-ol (30B2) (100 mg, 0.617 mmol), the title compound 30 (32 mg, 0.0760 mmol) was obtained.

Sources & evidence

ORD record
ord-3be54aa8a6314fad96d0abb9b85d0719
Source dataset
uspto-grants-2015_07
Patent number
US09090594B2

Reaction notes

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