HCID 71261520, compound → HCID 71261457, compound

HRID 1528146Notes

Reaction equation

NC1SC(C2C(F)=CC=CC=2F)=NC=1C(NC1C(OCCC2COC(C)(C)O2)=NC=NC=1)=O.[NH2:34][C:35]1[S:39][C:38]([C:40]2[C:45]([F:46])=[CH:44][CH:43]=[CH:42][C:41]=2[F:47])=[N:37][C:36]=1[C:48]([NH:50][C:51]1[C:52]([O:57][CH2:58][CH:59]2[CH2:63][O:62]C(C)(C)[O:60]2)=[N:53][CH:54]=[N:55][CH:56]=1)=[O:49]>>[NH2:34][C:35]1[S:39][C:38]([C:40]2[C:41]([F:47])=[CH:42][CH:43]=[CH:44][C:45]=2[F:46])=[N:37][C:36]=1[C:48]([NH:50][C:51]1[C:52]([O:57][CH2:58][CH:59]([OH:60])[CH2:63][OH:62])=[N:53][CH:54]=[N:55][CH:56]=1)=[O:49]

Participants

Reactant 2

HCID 71261520HCID 71261520, compound

HCID 71261581HCID 71261581, compound

Product 1

HCID 71261457HCID 71261457, compoundYield 49.3%

Procedure

Following the procedure described in Example 48, and substituting Compound 38 in Step (1) with 5-amino-2-(2,6-difluorophenyl)-N-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)pyrimidin-5-yl)thiazole-4-carboxamide (36) (20 mg, 0.0432 mmol), the title compound 51 (9 mg, 0.0213 mmol) was obtained.

Sources & evidence

ORD record: ord-e0c6787033724ea89645713ac3d94c8a
Source dataset: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09090594B2

Reaction notes

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