HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 89525592, compound → HCID 89525610, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 89525592 | HCID 89525592 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 89525610 | HCID 89525610 | 100.4% |
Reaction Steps
A solution of 2.25 g (10 mmol, 1 eq) of 2-[azido-(3-fluoromethyloxetan-3-yl)methyl]-5-methylfuran in 40 ml of ethanol in the presence of 378 mg (17% by weight) of palladium on carbon at 10% was stirred at hydrogen atmospheric pressure for two and a half hours. The reaction medium was filtered and the filtrate was evaporated. 2.0 g of C-(5-methylfuran-2-yl)-C-(3-fluoromethyloxetan-3-yl)methylamine were obtained in the form of a grayish oil. Yield=100%. TLC SiO2/Heptane:EtOAc (70/30), developing with KMnO4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090596B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-a0644cb681d94fcc89b583f5796a13d4 |
| Source note | uspto-grants-2015_07 |