反应详情

A solution of 7.83 g (26 mmol, 1 eq) of (2-hydroxy-3-nitrophenyl)-((R)-3-hydroxypyrrolidin-1-yl)methanone at 84% in 100 ml of methanol was stirred at hydrogen atmospheric pressure in the presence of 728 mg (10% by weight) of palladium on carbon at 10% for 16 hours. The reaction medium was filtered and the filtrate was evaporated. The residue was chromatographed on silica gel (column puriFlash IR-50SI/300G, Spot II) eluted with dichloromethane/methanol (96/4). 3.63 g of (3-amino-2-hydroxyphenyl)-((R)-3-hydroxypyrrolidin-1-yl)methanone were obtained in the form of a yellow amorphous solid. Yield=63%. SiO2/CH2Cl2 90: MeOH 10, developing with KMnO4.

1. filtrationThe reaction medium was filtered
2. customthe filtrate was evaporated
3. customThe residue was chromatographed on silica gel (column puriFlash IR-50SI/300G, Spot II)
4. washeluted with dichloromethane/methanol (96/4)