HCID 55131721, compound → HCID 62916971, compound

HRID 1528195Notes

Reaction equation

HRID 1528195 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-])=O)[CH:10]=2)=[O:8])[CH2:3]1>C(O)C.[Pd]>[NH2:15][C:11]1[CH:10]=[C:9]([C:7]([N:4]2[CH2:5][CH2:6][CH:2]([OH:1])[CH2:3]2)=[O:8])[CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 1

HCID 55131721HCID 55131721, compound

Product 1

HCID 62916971HCID 62916971, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2.36 g of (3-hydroxypyrrolidin-1-yl)-(3-nitrophenyl)methanone in 40 ml of ethanol and in the presence of 300 mg of palladium on carbon at 10% was stirred under hydrogen atmospheric pressure for 2 days. The reaction medium was filtered through celite and washed with 50 ml of ethanol. The solvent was concentrated to 30 ml. This solution of (3-aminophenyl)-(3-hydroxypyrrolidin-1-yl)methanone was used in the next step. Supposed yield=100%.

Workup

  1. filtrationThe reaction medium was filtered through celite
  2. washwashed with 50 ml of ethanol
  3. concentrationThe solvent was concentrated to 30 ml

Sources & evidence

ORD record
ord-1aea4daf00e54f8ea256074ab1bc4832
Source dataset
uspto-grants-2015_07
Patent number
US09090596B2

Reaction notes

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