Tin tetrachloride → HCID 131733214, compound

Participants

Reaction Steps

A solution of 2.64 g of methyl (S)-1-(2-chloro-3-nitrobenzoyl)pyrrolidine-2-carboxylate and 10.0 g of tin chloride in 60 ml of methanol was refluxed for 1 hour. The reaction medium was filtered and the filtrate was concentrated by half its volume and extracted with ethyl acetate (3×50 ml). The organic phases were combined, dried over magnesium sulfate and evaporated. 2.20 g of methyl (S)-1-(3-amino-2-chlorobenzoyl)pyrrolidine-2-carboxylate were obtained. Yield=92%.

Provenance & Evidence