反应详情

温度

5 °C

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. to obtain a mixture. The mixture was stirred and added to a solution of 2-chloromandelic acid (0.106 g, 0.57 mmol) in TFE (1 mL) at 40° C. Stirring of the resulting solution was continued for about 1 h and it was subsequently cooled to 5° C. The mixture was kept at 5° C. overnight and then a sample (1 ml) was taken from the mixture and evaporated to dryness under reduced pressure at 40° C. to give amorphous Nilotinib 2-chloromandelate.

1. customto obtain a mixture
2. stirringStirring of the resulting solution
3. waitThe mixture was kept at 5° C. overnight
4. customevaporated to dryness under reduced pressure at 40° C.