反应详情

温度

5 °C

Nilotinib base (0.300 g, 0.57 mmol) was dissolved in TFE (2 mL) at 40° C. to obtain a mixture. The mixture was stirred and added to a solution of citric acid (0.036 g, 0.19 mmol) in TFE (1 mL) at 40° C. The resulting clear solution was stirred for about 4 h and it was subsequently cooled to 5° C. The mixture was kept at 5° C. overnight while stirring and then a sample (1 ml) was taken from the mixture and evaporated to dryness under reduced pressure at 40° C. to give amorphous Nilotinib citrate.

1. customto obtain a mixture
2. stirringThe resulting clear solution was stirred for about 4 h
3. stirringwhile stirring
4. customevaporated to dryness under reduced pressure at 40° C.