Glutarimide → 1-(2-{4-[3-(3,4-Dimethoxy-phenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-pyrazol-1-yl]-piperidin-1-yl}-2-oxo-ethyl)-piperidine-2,6-dione

Participants

Role	Name	HCID	Charge
Reactant	Glutarimide	HCID 70726	—
Reactant	2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one	HCID 66616609	—
Product	1-(2-{4-[3-(3,4-Dimethoxy-phenyl)-4,4-dimethyl-5-oxo-4,5-dihydro-pyrazol-1-yl]-piperidin-1-yl}-2-oxo-ethyl)-piperidine-2,6-dione	HCID 25116539	—

Reaction Steps

Prepared analogously as described for example 1 using 2-[1-(chloroacetyl)piperidin-4-yl]-5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (compound A1) and 2,6-dioxopiperidine as starting compounds.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09090597B2
Source dataset	uspto-grants-2015_07
ORD ID	ord-e1cdfe1d98344155abffbd917b32e124
Source note	uspto-grants-2015_07