反应详情

To a solution of 0.860 g (S)-methyl 5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinate in 9 mL tetrahydrofuran was added 3 mL of a 1M solution of lithium hydroxide in water and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was acidified by addition of 1M hydrochloric acid till pH=2. Ethyl acetate was added and the phases were separated. The organic phase was dried over MgSO4 and the solvent was removed to yield 830 mg (100%) of the title compound as light yellow solid, MS 344.1 (M−H)−.

1. customThe solvent was evaporated
2. additionthe residue was acidified by addition of 1M hydrochloric acid till pH=2
3. additionEthyl acetate was added
4. customthe phases were separated
5. dry with materialThe organic phase was dried over MgSO4
6. customthe solvent was removed