HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-3-fluorophenylboronic Acid → 5-(4-Chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-3-fluorophenylboronic Acid | HCID 2778656 | — |
| Reactant | 5-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid | HCID 58192592 | — |
| Product | 5-(4-Chloro-3-fluorophenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid | HCID 66678612 | — |
Reaction Steps
The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-(4-chloro-3-fluorophenyl)-boronic acid, (CAN 137504-86-0) as starting materials; LC-MS (UV peak area/ESI) 96%, 348.0058 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090599B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-262bfb2459ba433087ce89713da12a3c |
| Source note | uspto-grants-2015_07 |