Boronic acid, (4-ethylphenyl)- → 5-(4-Ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

反応式

Br[C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[CH2:17]([C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1)[CH3:18]>>[CH2:17]([C:19]1[CH:24]=[CH:23][C:22]([C:2]2[C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:14]([OH:16])=[O:15])=[CH:21][CH:20]=1)[CH3:18]

参加物

反応物 2

HCID 2734352Boronic acid, (4-ethylphenyl)-

HCID 581925925-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

生成物 1

HCID 666784865-(4-Ethylphenyl)-6-(2,2,2-trifluoroethoxy)nicotinic acid

実験手順

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-(4-ethylphenyl)-boronic acid, (CAN 63139-21-9) as starting materials; LC-MS (UV peak area/ESI) 95.8%, 324.0859 (M−H)−.

出典と根拠

ORDレコード: ord-0acbd50c982d438f89174a284dd137fc
出典データセット: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09090599B2

反応ノート

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