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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528398Generated: November 3, 2026

3,4-Difluorobenzeneboronic acid → 6-(Cyclopropylmethoxy)-5-(3,4-difluorophenyl)nicotinic acid

https://huagongshe.com/reaction/1528398

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Difluorobenzeneboronic acidHCID 2734337—
Reactant5-Bromo-6-(cyclopropylmethoxy)nicotinic acidHCID 21109708—
Product6-(Cyclopropylmethoxy)-5-(3,4-difluorophenyl)nicotinic acidHCID 66678619—

Reaction Steps

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAN 912454-38-7) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials; MS (ESI): 304.2 (M−H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090599B2
Source datasetuspto-grants-2015_07
ORD IDord-5bf3bdedf4494b4fa631ca64e14e2392
Source noteuspto-grants-2015_07