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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528401Generated: November 2, 2026

(4-Chloro-3-methylphenyl)boronic acid → 5-(4-Chloro-3-methylphenyl)-6-(2-methoxyethoxy)nicotinic acid

https://huagongshe.com/reaction/1528401

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Chloro-3-methylphenyl)boronic acidHCID 3786632—
Reactant5-Bromo-6-(2-methoxy-ethoxy)-nicotinic acidHCID 21109705—
Product5-(4-Chloro-3-methylphenyl)-6-(2-methoxyethoxy)nicotinic acidHCID 66678620—

Reaction Steps

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2-methoxyethoxy)-3-pyridinecarboxylic acid (CAN 912454-34-3) and B-(4-chloro-3-methylphenyl)-boronic acid (CAN 161950-10-3) as starting materials; LC-MS (UV peak area/ESI) 94%, 322.0842 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090599B2
Source datasetuspto-grants-2015_07
ORD IDord-30b65ff26dca4a68868f85759bef7dd0
Source noteuspto-grants-2015_07