5-Aminomethyl-3-isopropylisoxazole → HCID 56929658, compound

HRID 1528406Notes

Reaction equation

HRID 1528406 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20](O)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1)[CH3:25]>>[CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH:32][C:20]([C:10]2[CH:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=2)=[O:21])[O:28][N:27]=1)([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 64838985-Aminomethyl-3-isopropylisoxazoleHCID 66687043HCID 66687043, compound

Product 1

HCID 56929658HCID 56929658, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 3-(1-methylethyl)-5-isoxazolemethanamine as starting materials; LC-MS (UV peak area/ESI) 100%, 454.1134 (M+H)+.

Sources & evidence

ORD record
ord-4a30d69092564caaa118cf4b3510b478
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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