[(1-propyl-1H-pyrazol-3-yl)methyl]amine → 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-propyl-1H-pyrazol-3-ylmethyl)-amide

HRID 1528408Notes

Reaction equation

HRID 1528408 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20](O)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1.[CH2:23]([N:26]1[CH:30]=[CH:29][C:28]([CH2:31][NH2:32])=[N:27]1)[CH2:24][CH3:25]>>[CH2:23]([N:26]1[CH:30]=[CH:29][C:28]([CH2:31][NH:32][C:20]([C:10]2[CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:12][N:11]=2)=[O:21])=[N:27]1)[CH2:24][CH3:25]

Participants

3

Reactant 2

HCID 19576818[(1-propyl-1H-pyrazol-3-yl)methyl]amineHCID 66687043HCID 66687043, compound

Product 1

HCID 569296604-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-propyl-1H-pyrazol-3-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 1-propyl-1H-pyrazole-3-methanamine (CAS Registry No. 1006333-47-6) as starting materials; LC-MS (UV peak area/ESI) 100%, 453.1306 (M+H)+.

Sources & evidence

ORD record
ord-3fc3a1c50393479297e513d6f493ace0
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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