(2-Isopropylthiazol-4-yl)methanamine → 4-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2-isopropyl-thiazol-4-ylmethyl)-amide

HRID 1528410Notes

Reaction equation

HRID 1528410 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH2:32])[N:30]=1)[CH3:25]>>[CH:24]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH:32][C:20]([C:10]2[CH:9]=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[C:13]([O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:12][N:11]=2)=[O:22])[N:30]=1)([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 16427107(2-Isopropylthiazol-4-yl)methanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569297564-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (2-isopropyl-thiazol-4-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 2-(1-methylethyl)-4-thiazole-methanamine, as starting materials; LC-MS (UV peak area/ESI) 80%, 470.902 (M+H)+.

Sources & evidence

ORD record
ord-8df86ba97b4c4a9091a8859ac0527068
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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