HuagongsheHuagongshe Chemistry Print Report · For research reference only
C-(5-Trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride → 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(5-trifluoromethyl-[1,2,4]oxadiazol-3-ylmethyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | C-(5-Trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride | HCID 66686733 | — |
| Reactant | 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid | HCID 66686971 | — |
| Product | 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(5-trifluoromethyl-[1,2,4]oxadiazol-3-ylmethyl)-nicotinamide | HCID 56928271 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and C-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride (example AI), LC-MS (UV peak area/ESI) 93%, 479.035 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090599B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-b32e21a4c0164e31929c3386fca553ac |
| Source note | uspto-grants-2015_07 |