(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → 5-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)pyridazine-3-carboxamide

HRID 1528427Notes

Reaction equation

HRID 1528427 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([OH:22])=O)[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.Cl.[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20]([NH:32][CH2:31][C:29]3[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=3)=[O:22])[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21292276(3-Methoxyisoxazol-5-yl)methanamine hydrochlorideHCID 66678582HCID 66678582, compound

Product 1

HCID 666786235-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(2,2,2-trifluoroethoxy)pyridazine-3-carboxamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 3-methoxy-5-isoxazole-methanamine hydrochloride as starting materials, 443.1 (M+H)+.

Sources & evidence

ORD record
ord-911d9cc8e91447c3b8eaa12b28a03f28
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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