(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → 4-(3,4-dichlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)pyrimidine-2-carboxamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:13][N:12]=[C:11]([C:21](O)=[O:22])[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:25][O:26][C:27]1[CH:31]=[C:30]([CH2:32][NH2:33])[O:29][N:28]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[C:14]([O:15][CH2:16][C:17]([F:20])([F:18])[F:19])=[CH:13][N:12]=[C:11]([C:21]([NH:33][CH2:32][C:30]3[O:29][N:28]=[C:27]([O:26][CH3:25])[CH:31]=3)=[O:22])[N:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]Participants
3
Procedure
The title compound was synthesized in analogy to Example 1, using 4-(3,4-dichloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrimidine-2-carboxylic acid (example AA) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials, 477.0 (M+H)+.
Sources & evidence
- ORD record
- ord-f60178c29aa84e74b4e222e081780592
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090599B2
Reaction notes
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