5-(1-Methylethyl)-3-isoxazolemethanamine → 5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-N-((5-isopropylisoxazol-3-yl)methyl)nicotinamide

HRID 1528435Notes

Reaction equation

HRID 1528435 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH3:22][CH:23]([C:25]1[O:29][N:28]=[C:27]([CH2:30][NH2:31])[CH:26]=1)[CH3:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:31][CH2:30][C:27]2[CH:26]=[C:25]([CH:23]([CH3:24])[CH3:22])[O:29][N:28]=2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 280651515-(1-Methylethyl)-3-isoxazolemethanamineHCID 666874825-(4-Chlorophenyl)-6-(cyclopropylmethoxy)nicotinic acid

Product 1

HCID 569285925-(4-chlorophenyl)-6-(cyclopropylmethoxy)-N-((5-isopropylisoxazol-3-yl)methyl)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-nicotinic acid (CAS Registry No. 1018782-76-7) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials, 426.2 (M+H)+.

Sources & evidence

ORD record
ord-d1b4ecec8dba4d7e94ae899bda9a74a1
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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