HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-5-(4-Chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinic acid → (S)-5-(4-chlorophenyl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-5-(4-Chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinic acid | HCID 66678484 | — |
| Reactant | [3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]methanamine hydrochloride | HCID 66687518 | — |
| Product | (S)-5-(4-chlorophenyl)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinamide | HCID 86663145 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using (S)-5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinic acid (Example AO) and C-(3-trifluoromethyl-[1,2,4]oxadiazol-5-yl)-methylamine hydrochloride (CAS registry No. 944905-93-5; example AK) as starting materials; MS: 493.1 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090599B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-4561835cf1444128beaf796eb0ef7c0d |
| Source note | uspto-grants-2015_07 |