5-Aminomethyl-3-isopropylisoxazole → HCID 56928696, compound

HRID 1528447Notes

Reaction equation

HRID 1528447 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[N:9]=2)=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1)[CH3:25]>>[CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH:32][C:20]([C:10]2[N:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[CH:12][N:11]=2)=[O:22])[O:28][N:27]=1)([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 64838985-Aminomethyl-3-isopropylisoxazoleHCID 66686794HCID 66686794, compound

Product 1

HCID 56928696HCID 56928696, compound

Procedure

The title compound was synthesized in analogy to Example 41, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrimidine-2-carboxylic acid (example W) and 3-(1-methylethyl)-5-isoxazolemethanamine (CAN 543713-30-0) as starting materials; LC-MS (UV peak area/ESI) 98.43%, 455.0 (M+H)+.

Sources & evidence

ORD record
ord-bdcc456cd8e24b549b6d20ae81af095f
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

Loading…