[(2-Isopropyl-1,3-thiazol-4-yl)methyl]amine dihydrochloride → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-isopropyl-thiazol-4-ylmethyl)-amide
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:4][CH:3]=1.Cl.Cl.[CH3:24][CH:25]([C:27]1[S:28][CH:29]=[C:30]([CH2:32][NH2:33])[N:31]=1)[CH3:26]>>[CH:25]([C:27]1[S:28][CH:29]=[C:30]([CH2:32][NH:33][C:14]([C:12]2[CH:11]=[CH:10][C:9]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[N:31]=1)([CH3:26])[CH3:24]Participants
3
Procedure
The title compound was synthesized in analogy to Example 41, using 6-(4-chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 2-(1-methylethyl)-4-thiazole-methanamine dihydrochloride (CAN 1171981-10-4) as starting materials, LC-MS (peak area/EIC) 97.9%, 442.0 (M+H)+.
Sources & evidence
- ORD record
- ord-1e774bc6408e4d74b992c0e6c4c337ee
- Source dataset
- uspto-grants-2015_07
- Patent number
- US09090599B2
Reaction notes
Loading…