HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(1-Methylethyl)-3-isoxazolemethanamine → 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(1-Methylethyl)-3-isoxazolemethanamine | HCID 28065151 | — |
| Reactant | 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 66678483 | — |
| Product | 6-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide | HCID 56928902 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 41, using 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example AF) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAN 154016-49-6) as starting materials; LC-MS (UV peak area/ESI) 97.1%, 454.6 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09090599B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-8abc0b796a614784889aad14b893c096 |
| Source note | uspto-grants-2015_07 |