5-(1-Methylethyl)-3-isoxazolemethanamine → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide

HRID 1528457Notes

Reaction equation

HRID 1528457 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][CH:19]2[CH2:21][CH2:20]2)=[CH:4][CH:3]=1.[CH3:22][CH:23]([C:25]1[O:29][N:28]=[C:27]([CH2:30][NH2:31])[CH:26]=1)[CH3:24]>>[CH:23]([C:25]1[O:29][N:28]=[C:27]([CH2:30][NH:31][C:14]([C:12]2[CH:11]=[CH:10][C:9]([O:17][CH2:18][CH:19]3[CH2:21][CH2:20]3)=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:16])[CH:26]=1)([CH3:24])[CH3:22]

Participants

3

Reactant 2

HCID 280651515-(1-Methylethyl)-3-isoxazolemethanamineHCID 666786056-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 569289046-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (5-isopropyl-isoxazol-3-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41 using 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAN 154016-49-6) as starting materials, LC-MS (peak area/EIC) 98.2%, 426.4 (M+H)+.

Sources & evidence

ORD record
ord-b1be3e6739f642539e2855ab8051fa47
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

Loading…