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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1528465Generated: November 3, 2026

(2-(tert-Butyl)thiazol-4-yl)methanamine → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amide

https://huagongshe.com/reaction/1528465

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-(tert-Butyl)thiazol-4-yl)methanamineHCID 16494974—
Reactant6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acidHCID 66678605—
Product6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (2-tert-butyl-thiazol-4-ylmethyl)-amideHCID 56929006—

Reaction Steps

The title compound was synthesized in analogy to Example 41, using 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 2-(1,1-dimethylethyl)-4-thiazolemethanamine (CAN 937656-81-0) as starting materials; LC-MS (UV peak area/ESI) 97.7%, 456.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09090599B2
Source datasetuspto-grants-2015_07
ORD IDord-19e36c0fe304486b846344374e12a6a1
Source noteuspto-grants-2015_07