5-Aminomethyl-3-isopropylisoxazole → HCID 56929096, compound

HRID 1528466Notes

Reaction equation

HRID 1528466 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14](O)=[O:15])[CH:11]=[CH:10][C:9]=2[O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1)[CH3:25]>>[CH:24]([C:26]1[CH:30]=[C:29]([CH2:31][NH:32][C:14]([C:12]2[CH:11]=[CH:10][C:9]([O:17][CH2:18][C:19]([F:20])([F:22])[F:21])=[C:8]([C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=3)[N:13]=2)=[O:15])[O:28][N:27]=1)([CH3:25])[CH3:23]

Participants

3

Reactant 2

HCID 64838985-Aminomethyl-3-isopropylisoxazoleHCID 666784836-(4-Chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 56929096HCID 56929096, compound

Procedure

The title compound was synthesized in analogy to Example 41 using 6-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-2-pyridine carboxylic acid (example AF) and 3-(1-methylethyl)-5-isoxazolemethanamine (CAN 543713-30-0) as starting materials; LC-MS (UV peak area/ESI) 100.0%, 454.4 (M+H)+.

Sources & evidence

ORD record
ord-53af231e20d24ff4966b92e18f9da60c
Source dataset
uspto-grants-2015_07
Patent number
US09090599B2

Reaction notes

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